Question 1

Which of the following are maternal effect genes that control the orientation of the egg and thus the Drosophila embryo?

Accepted Answer

A)   homeotic genes
B)   segmentation genes
C)   egg-polarity genes
D)   morphogens

Question 2

Which of the following statements about the DNA in one of your brain cells is true?

Accepted Answer

A)   Most of the DNA codes for protein.
B)   The majority of genes are likely to be transcribed.
C)   It is the same as the DNA in one of your liver cells.
D)   Each gene lies immediately adjacent to an enhancer.

Question 3

Among the newly discovered small noncoding RNAs, one type helps to reestablish ethylation patterns during gamete formation and blocks expression of some transposons. Which of the following types of RNA is responsible for this function?

Accepted Answer

A)   miRNA
B)   piRNA
C)   lncRNA
D)   siRNA

Question 4

A researcher introduces double-stranded RNA into a culture of mammalian cells and can identify its location or that of its smaller subsections experimentally, using a fluorescent probe. Some time later, she finds that the introduced strand separates into single-stranded RNAs, one of which is degraded. What does this enable the remaining strand to do?

Accepted Answer

A)   attach to histones in the chromatin
B)   bind to complementary regions of target mRNAs
C)   activate other siRNAs in the cell
D)   bind to noncomplementary RNA sequences

Question 5

A researcher introduces double-stranded RNA into a culture of mammalian cells and can identify its location or that of its smaller subsections experimentally, using a fluorescent probe. When she finds that the introduced strand separates into single-stranded RNAs, what other evidence of this single-stranded RNA piece's activity would she find?

Accepted Answer

A)   She can measure the degradation rate of the remaining single strand.
B)   The rate of accumulation of the polypeptide encoded by the target mRNA is reduced.
C)   The amount of miRNA is multiplied by its replication.
D)   The cell's translation ability is entirely shut down.

Question 6

In positive control of several sugar metabolism-related operons, the cAMP receptor protein (CRP) binds to DNA to stimulate transcription. Which of the following environmental conditions causes an increase in CRP activity in stimulating transcription?

Accepted Answer

A)   an increase in glucose and an increase in cAMP
B)   a decrease in glucose and an increase in cAMP
C)   an increase in glucose and a decrease in cAMP
D)   a decrease in glucose and a decrease in the repressor

Question 7

Mutations in which of the following genes lead to transformations in the identity of entire body parts?

Accepted Answer

A)   segmentation genes
B)   egg-polarity genes
C)   homeotic genes
D)   inducers

Question 8

Which of the following processes do normal proto-oncogenes typically exhibit?

Accepted Answer

A)   They normally suppress tumor growth.
B)   They enhance tumor growth.
C)   They stimulate normal cell growth and division.
D)   They are underexpressed in cancer cells.

Question 9

The cAMP receptor protein (CRP) is said to be responsible for positive regulation of the lac operon because ________.

Accepted Answer

A)   CRP binds cAMP
B)   CRP binds to the CAP-binding site
C)   CRP prevents binding of the repressor to the operator
D)   CRP bound to the CRP-binding site stimulates the transcription of the lac operon

Question 10

The bicoid gene product is normally localized to the anterior end of the embryo. If large amounts of the product were injected into the posterior end as well, which of the following developmental events would occur?

Accepted Answer

A)   The embryo would grow extra wings and legs.
B)   The embryo would probably show no anterior development and die.
C)   Anterior structures would form in both ends of the embryo.
D)   The embryo would develop normally.

Question 11

Which axis in the embryo does the protein product of the bicoid gene in Drosophila determine?

Accepted Answer

A)   anterior-posterior axis
B)   anterior-lateral axis
C)   posterior-dorsal axis
D)   posterior-ventral axis

Question 12

Suppose an experimenter becomes proficient with a technique that allows her to move DNA sequences within a prokaryotic genome. If a researcher moves the repressor gene (lacI) , along with its promoter, to a position at some several thousand base pairs away from its normal position, which of the following results would be expected?

Accepted Answer

A)   The repressor will no longer bind to the operator.
B)   The repressor will no longer bind to the inducer.
C)   The lac operon will be expressed continuously.
D)   The lac operon will function normally.

Question 13

Cell differentiation always involves

Accepted Answer

A)   transcription of the myoD gene.
B)   the movement of cells.
C)   the production of tissue-specific proteins.
D)   the selective loss of certain genes from the genome.

Question 14

According to the lac operon model proposed by Jacob and Monod, what is predicted to occur if the operator is removed from the operon?

Accepted Answer

A)   The lac operon would be transcribed continuously.
B)   Only lacZ would be transcribed.
C)   Only lacY would be transcribed.
D)   Galactosidase permease would be produced, but would be incapable of transporting lactose.

Question 15

Imagine that you've isolated a yeast mutant that contains histones resistant to acetylation. What phenotype would you predict for this mutant?

Accepted Answer

A)   The mutant will grow rapidly.
B)   The mutant will require galactose for growth.
C)   The mutant will show decreased levels of gene expression.
D)   The mutant will show increased levels of gene expression.

Question 16

If a particular operon encodes enzymes for making an essential amino acid and is regulated like the trp operon, then

Accepted Answer

A)   the amino acid inactivates the repressor.
B)   the repressor is active in the absence of the amino acid.
C)   the amino acid acts as a corepressor.
D)   the amino acid turns on transcription of the operon.

Question 17

What would be the result of a mutation in a maternal effect gene in a female Drosophila?

Accepted Answer

A)   She will not develop past the early embryonic stage.
B)   All of her offspring will show the mutant phenotype, regardless of their genotype.
C)   Only her male offspring will show the mutant phenotype.
D)   Only her female offspring will show the mutant phenotype.

Question 18

A genetic test to detect predisposition to cancer would likely examine the APC gene for involvement in which type(s) of cancer?

Accepted Answer

A)   colorectal only
B)   lung and breast
C)   lung only
D)   lung and prostate

Question 19

How do steroid hormones produce their effects in cells?

Accepted Answer

A)   by binding to the regulatory gene in an operon
B)   by activating translation of certain mRNAs
C)   by promoting the degradation of specific mRNAs
D)   by binding to intracellular receptors and promoting transcription of specific genes

Question 20

Forms of the Ras protein found in tumors usually cause which of the following events to occur?

Accepted Answer

A)   DNA replication to stop
B)   cell-to-cell adhesion to be nonfunctional
C)   cell division to cease
D)   excessive cell division

Exam 18: Regulation of Gene Expression

Imagine that you've isolated a yeast mutant that contains histones resistant to acetylation. What phenotype would you predict for this mutant?

Correct Answer
verified

Correct Answer
verified

Which axis in the embryo does the protein product of the bicoid gene in Drosophila determine?

Correct Answer
verified

Among the newly discovered small noncoding RNAs, one type helps to reestablish ethylation patterns during gamete formation and blocks expression of some transposons. Which of the following types of RNA is responsible for this function?

Correct Answer
verified

Which of the following are maternal effect genes that control the orientation of the egg and thus the Drosophila embryo?

Correct Answer
verified

Correct Answer
verified

The cAMP receptor protein (CRP) is said to be responsible for positive regulation of the lac operon because ________.

Correct Answer
verified

According to the lac operon model proposed by Jacob and Monod, what is predicted to occur if the operator is removed from the operon?

Correct Answer
verified

Which of the following processes do normal proto-oncogenes typically exhibit?

Correct Answer
verified

How do steroid hormones produce their effects in cells?

Correct Answer
verified

If a particular operon encodes enzymes for making an essential amino acid and is regulated like the trp operon, then

Correct Answer
verified

A genetic test to detect predisposition to cancer would likely examine the APC gene for involvement in which type(s) of cancer?

Correct Answer
verified

What would be the result of a mutation in a maternal effect gene in a female Drosophila?

Correct Answer
verified

Forms of the Ras protein found in tumors usually cause which of the following events to occur?

Correct Answer
verified

In positive control of several sugar metabolism-related operons, the cAMP receptor protein (CRP) binds to DNA to stimulate transcription. Which of the following environmental conditions causes an increase in CRP activity in stimulating transcription?

Correct Answer
verified

Which of the following statements about the DNA in one of your brain cells is true?

Correct Answer
verified

The bicoid gene product is normally localized to the anterior end of the embryo. If large amounts of the product were injected into the posterior end as well, which of the following developmental events would occur?

Correct Answer
verified

Cell differentiation always involves

Correct Answer
verified

Correct Answer
verified

Mutations in which of the following genes lead to transformations in the identity of entire body parts?

Correct Answer
verified

Exam 18: Regulation of Gene Expression

Imagine that you've isolated a yeast mutant that contains histones resistant to acetylation. What phenotype would you predict for this mutant?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

Which axis in the embryo does the protein product of the bicoid gene in Drosophila determine?

Correct AnswerverifiedShow Answer

Among the newly discovered small noncoding RNAs, one type helps to reestablish ethylation patterns during gamete formation and blocks expression of some transposons. Which of the following types of RNA is responsible for this function?

Correct AnswerverifiedShow Answer

Which of the following are maternal effect genes that control the orientation of the egg and thus the Drosophila embryo?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

The cAMP receptor protein (CRP) is said to be responsible for positive regulation of the lac operon because ________.

Correct AnswerverifiedShow Answer

According to the lac operon model proposed by Jacob and Monod, what is predicted to occur if the operator is removed from the operon?

Correct AnswerverifiedShow Answer

Which of the following processes do normal proto-oncogenes typically exhibit?

Correct AnswerverifiedShow Answer

How do steroid hormones produce their effects in cells?

Correct AnswerverifiedShow Answer

If a particular operon encodes enzymes for making an essential amino acid and is regulated like the trp operon, then

Correct AnswerverifiedShow Answer

A genetic test to detect predisposition to cancer would likely examine the APC gene for involvement in which type(s) of cancer?

Correct AnswerverifiedShow Answer

What would be the result of a mutation in a maternal effect gene in a female Drosophila?

Correct AnswerverifiedShow Answer

Forms of the Ras protein found in tumors usually cause which of the following events to occur?

Correct AnswerverifiedShow Answer

In positive control of several sugar metabolism-related operons, the cAMP receptor protein (CRP) binds to DNA to stimulate transcription. Which of the following environmental conditions causes an increase in CRP activity in stimulating transcription?

Correct AnswerverifiedShow Answer

Which of the following statements about the DNA in one of your brain cells is true?

Correct AnswerverifiedShow Answer

The bicoid gene product is normally localized to the anterior end of the embryo. If large amounts of the product were injected into the posterior end as well, which of the following developmental events would occur?

Correct AnswerverifiedShow Answer

Cell differentiation always involves

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

Mutations in which of the following genes lead to transformations in the identity of entire body parts?

Correct AnswerverifiedShow Answer

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